A developing company is having a meeting in their headquarters over their newly released product, the "i Babe", which is a life-sized, realistic replica of a nude woman which functions as an MP3 player.
The boss (Richard Gere) listens to his various workers (Kate Bosworth, Aasif Mandvi and Jack Mc Brayer) argue over the placement of a fan that was built into the genital region of the i Babe, which is dismembering the penises of teenage boys who attempt to have sex with them.
Afterward, a deadly earthquake rumbles and mankind is lost. Beth (Kate Winslet) is a single businesswoman who goes on a blind date with Davis (Hugh Jackman), the city's most eligible bachelor.
However, a few years later the only survivor, a crippled Calvin, finds Baxter's laptop still working despite viral infections. When the two arrive together at a restaurant, Beth is shocked when he removes his scarf, revealing a pair of testicles dangling from his neck.
While Robin attempts to connect with various women through speed dating including Lois Lane (Uma Thurman) and Supergirl (Kristen Bell), Batman encounters his ex Wonder Woman (Leslie Bibb) and attempts to stop Penguin from detonating Supergirl, who later turns out to be the Riddler (Will Carlough) in disguise, which Batman already knew and was screwing with Robin, who kissed "her" moments before unveiling.
A faux-Public service announcement about children stuck in machines and how adults' criticism of these particular machines affect the feelings of the children stuck inside the machines.
She cradles him and apologizes; covered and surrounded by his excrement on the road, she exclaims that it is the "most beautiful thing" she has ever seen and accepts his marriage proposal.
(In the end credits, Julie and Doug are mistakenly renamed Vanessa and Jason by Rocky Russo, Jeremy Sosenko, Steve Carr, Peter Farrelly, and Charles B. Neil (Kieran Culkin) is working a night shift at a local grocery store.
When two friends of Davis (Roy Jenkins and Katie Finneran) come by, one of them convinces him to give Beth a kiss.The board members then agree to strongly emphasize the dangers of the product via its new commercials.Robin (Justin Long) and his cohort Batman (Jason Sudeikis) are in Gotham City at a speed dating establishment seeking out a bomb threat by their nemesis, Penguin (John Hodgman).The structure of the film released in some countries, like the United Kingdom and the Netherlands, differs. This turns out to be an April Fool's prank from Calvin's younger brother Baxter (Devin Eash), who cloned You Tube and hyper-inflated the views while working on his science project. As Calvin finishes ruining Baxter's laptop, their mother (Beth Littleford) enters, wearing the same shirt and shorts that the woman in the strip tease video wore, causing Calvin to flip out after realizing that he had masturbated to a video of his mother.Instead of a pitch, the films are connected by a group of three teenagers searching for the most banned film in the world, Movie 43, which will ultimately lead to the destruction of civilization. He also has visions, and finds semen from his erect crotch on his hand causing him to stare at his hand in shock and horror. as part of the Blu-ray Disc of Movie 43 as an unrated alternate cut of the film.